Autophagy

WG2 - Glycan dependent modulation of autophagy, endocytosis and lysosomal functions: cancer, lysosomal disorders and neurodegenerative diseases.
Objectives

Discussion and exchange of knowledge and know-how between INNOGLY participants will be focused on the role of glycans in the modulation of autophagy pathways.

  • Promote the investigation of the role of glycans in the modulation of autophagy, endocytosis and lysosomal functions in cancer.
  • Promote the investigation of the role of glycans in the modulation of autophagy, endocytosis and lysosomal functions in lysosomal disorders.
  • Promote the investigation of the role of glycans in the modulation of autophagy, endocytosis and lysosomal functions in neurodegenerative diseases.
Tasks
  • Employ advanced techniques to track the glycosylation pattern of glycoconjugates associated to autophagy, endocytosis and lysosomal functions.
  • Promote the identification of relevant model systems to investigate the glycan dependent modulation of autophagy, endocytosis and lysosomal functions.
  • Boost the development of modulators of autophagy, endocytosis and lysosomal functions (nanometric, small molecules and glycoconjugates).
WG Leader

Prof Eeva-Liisa ESKELINEN
eeva-liisa.eskelinen@utu.fi
+358505115631

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University of Turku
Institute of Biomedicine
Kiinamyllynkatu 10
Medisiina
Finland
Turku

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Report

COST Action CA18103 INNOGLY: INNOvation with GLYcans -new frontiers from synthesis to new biological targets.