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News

INNOGLY ITC Conference Grants Call for Grant Period 4
Inclusiveness Target Countries (ITC) Conference Grant is a COST-networking tool aimed to ...
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Closing Meeting of the INNOGLY COST Action, May 2-3, 2023, Heraklion, Crete, Greece
The Closing Meeting of the INNOGLY COST Action will take ...
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Chemical Reviews : Glycosciences Issue
The Chemical Reviews thematic issue is called “Glycosciences” to illustrate ...
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Training School on Conjugation of glycans onto nanomaterials: opportunities in therapy and diagnosis
Training School Conjugation of glycans onto nanomaterials: opportunities in therapy and ...
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Training School on the Conjugation of Glycans onto Nanomaterials
The COST action "INNOGLY" (Innovation with glycans: new frontiers from ...
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Pseudomonas aeruginosa lectin LecB impairs keratinocyte fitness by abrogating growth factor signalling

Lectins are glycan-binding proteins with no catalytic activity and ubiquitously expressed in nature. Numerous bacteria use lectins to efficiently bind to epithelia, thus facilitating tissue colonisation. Wounded skin is one of the preferred niches for Pseudomonas aeruginosa, which has developed diverse strategies to impair tissue repair processes and promote infection. Here, we analyse the effect of the P. aeruginosa fucose-binding lectin LecB on human keratinocytes and demonstrate that it triggers events in the host, upon binding to fucosylated residues on cell membrane receptors, which extend beyond its role as an adhesion molecule. We found that LecB associates with insulin-like growth factor-1 receptor and dampens its signalling, leading to the arrest of cell cycle. In addition, we describe a novel LecB-triggered mechanism to down-regulate host cell receptors by showing that LecB leads to insulin-like growth factor-1 receptor internalisation and subsequent missorting towards intracellular endosomal compartments, without receptor activation. Overall, these data highlight that LecB is a multitask virulence factor that, through subversion of several host pathways, has a profound impact on keratinocyte proliferation and survival.

https://www.life-science-alliance.org/content/2/6/e201900422

November 16, 2019

Events

Closing Meeting of the INNOGLY COST Action, May 2-3, 2023, Heraklion, Crete, Greece
The Closing Meeting of the INNOGLY COST Action will take ...
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Training School on Conjugation of glycans onto nanomaterials: opportunities in therapy and diagnosis
Training School Conjugation of glycans onto nanomaterials: opportunities in therapy and ...
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Training School on the Conjugation of Glycans onto Nanomaterials
The COST action "INNOGLY" (Innovation with glycans: new frontiers from ...
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RT @RobertPdeVries1: New paper alert, many thanks to my friends from the island to drag us into this.
#PLOSPathogens: Phenotypic effects of…

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RT @glycoworld: It is a huge honor to be invited to present at the upcoming @EUROCARB21. I look forward to this fascinating event, and to r…

RT @EUROCARB21: Many of you requested it: we are pleased to announce an exceptional extension for the submission of your abstracts for Oral…

RT @GordanLauc: Dr Parastoo Azadi @CCRCUGA – Detailed N and O-glycan analysis by MSn analysis. Plenary lecture at the 3rd Meeting of the…

POLICY STATEMENT:

Biomedicine and Molecular Biosciences Action CA18103 is funded by COST, which is supported by the EU Framework Programme Horizon 2020.

COST Action CA18103

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