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News

INNOGLY WG2: THE GLYCOBIOLOGY OF CELL METABOLIC PROCESSES AT THE NANOSCALE IN HUMAN PATHOLOGY
Dear students, don’t miss this unique opportunity to join the ...
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Young Researchers on stage: International Meeting of Young Researchers – INNOGLY & GLYCONanoPROBES Iasi – Romania, 20th-21st April 2023
The COST Actions 18103 INNOGLY and 18132 GLYCONanoPROBES have joined efforts to organize ...
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Glycans and Glycosciences
an intro for everyone
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Glycosaminoglycans: What Remains To Be Deciphered?
The article "Glycosaminoglycans: What remains to be deciphered?" by Serge ...
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Structural Glycobiology Summer School in Grenoble
Applications are open for Structural Glycoscience Summer School in Grenoble. Free ...
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Pseudomonas aeruginosa lectin LecB impairs keratinocyte fitness by abrogating growth factor signalling

Lectins are glycan-binding proteins with no catalytic activity and ubiquitously expressed in nature. Numerous bacteria use lectins to efficiently bind to epithelia, thus facilitating tissue colonisation. Wounded skin is one of the preferred niches for Pseudomonas aeruginosa, which has developed diverse strategies to impair tissue repair processes and promote infection. Here, we analyse the effect of the P. aeruginosa fucose-binding lectin LecB on human keratinocytes and demonstrate that it triggers events in the host, upon binding to fucosylated residues on cell membrane receptors, which extend beyond its role as an adhesion molecule. We found that LecB associates with insulin-like growth factor-1 receptor and dampens its signalling, leading to the arrest of cell cycle. In addition, we describe a novel LecB-triggered mechanism to down-regulate host cell receptors by showing that LecB leads to insulin-like growth factor-1 receptor internalisation and subsequent missorting towards intracellular endosomal compartments, without receptor activation. Overall, these data highlight that LecB is a multitask virulence factor that, through subversion of several host pathways, has a profound impact on keratinocyte proliferation and survival.

https://www.life-science-alliance.org/content/2/6/e201900422

November 16, 2019

Events

INNOGLY WG2: THE GLYCOBIOLOGY OF CELL METABOLIC PROCESSES AT THE NANOSCALE IN HUMAN PATHOLOGY
Dear students, don’t miss this unique opportunity to join the ...
Read More
Young Researchers on stage: International Meeting of Young Researchers – INNOGLY & GLYCONanoPROBES Iasi – Romania, 20th-21st April 2023
The COST Actions 18103 INNOGLY and 18132 GLYCONanoPROBES have joined efforts to organize ...
Read More
Structural Glycobiology Summer School in Grenoble
Applications are open for Structural Glycoscience Summer School in Grenoble. Free ...
Read More

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COST Action CA18103

COST (European Cooperation in Science and Technology) is a funding agency for research and innovation networks. Our Actions help connect research initiatives across Europe and enable scientists to grow their ideas by sharing them with their peers. This boosts their research, career and innovation.

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